Fig. 5
From: Kruppel-like factor 13 acts as a tumor suppressor in thyroid carcinoma by downregulating IFIT1
KLF13 negatively regulates IFIT1 expression in THCA cells. A Differentially expressed genes in siKLF13 cells as compared with siCtrl cells. Genes upregulated and downregulated were displayed as red and green dots. B Correlation between KLF13 and IFIT1 expression in human THCA samples based on TCGA database (n = 512). R = 0.28. P < 0.0001. C, D RT-qPCR results of IFIT1 after KLF13 knockdown or overexpression in K1 and TPC1 cells. ***P < 0.001. E Immunoblotting results of IFIT1 after KLF13 knockdown or overexpression in K1 and TPC1 cells. F Luciferase activity was measured to analyze the regulation of KLF13 on the transcription activity of IFIT1 promoter. ***P < 0.001