Fig. 5
From: Image-based modeling of vascular organization to evaluate anti-angiogenic therapy
Analysis of vessel average diameter versus vessel straightness. a Scatterplot of vessel average diameters vs vessel straightness of healthy tissue. b Scatterplot of vessel average diameters vs vessel straightness of control tumors and after tumors after antiangiogenic treatment. Each panel shows only one representative tissue sample for clarity. Black line contours 50% kernel density estimate area (KDE area) and grey line contours 90% KDE area. c Comparison of the 50% KDE Area in healthy tissue and in tumor tissue. n ≥ 4. d Comparison of the 50% KDE Area in tumor tissue and in tumor tissue after anti-angiogenic treatment with mG631 or Axitinib. n = 4–6. Error bars: ± SEM. Asterisks display results from statistical tests with *: P < 0.05, **: P < 0.01, ***: P < 0.001, ****: P < 0.0001