FPE score threshold | Phase 1 | Phase 2 |
---|
Years | Slope | R2 | ρ | P-value | Years | Slope | R2 | ρ | P-value |
---|
0 | – | – | – | – | – | – | – | – | – | – |
T0 (0 < x < 1) | 1960–2009 ↑ | 2.28 | 0.81 | 0.90 | 1.04E-18 | 2009–2021 ↓ | − 11.37 | 0.94 | 0.97 | 3.95E-08 |
T1 (1 ≤ x < 5) | 1965–2009 ↑ | 1.68 | 0.79 | 0.89 | 5.76E-16 | 2009–2021 ↓ | − 3.63 | 0.57 | 0.75 | 2.93E-03 |
T5 (5 ≤ x < 10) | 1970–2013 ↑ | 1.78 | 0.84 | 0.92 | 3.20E-18 | 2013–2021 ↓ | − 2.33 | 0.36 | 0.60 | 9.00E-02 |
T10 (10 ≤ x < 15) | 1973–2001 ↑ | 1.08 | 0.89 | 0.94 | 1.70E-14 | 2001–2021 ↑↑ | 3.46 | 0.79 | 0.89 | 7.07E-08 |
T15 (15 ≤ x < 20) | 1973–2003 ↑ | 0.85 | 0.84 | 0.92 | 3.68E-12 | 2003–2021 ↑↑ | 3.61 | 0.77 | 0.88 | 7.79E-07 |
T20 (20 ≤ x < 25) | 1973–2004 ↑ | 0.65 | 0.77 | 0.88 | 3.44E-11 | 2004–2021 ↑↑ | 3.88 | 0.87 | 0.93 | 1.83E-08 |
T25 (25 ≤ x < 30) | 1975–2004 ↑ | 0.49 | 0.61 | 0.78 | 2.94E-07 | 2004–2021 ↑↑ | 3.81 | 0.91 | 0.95 | 8.04E-10 |
T30 (30 ≤ x < 35) | 1975–2004 ↑ | 0.51 | 0.75 | 0.87 | 4.82E-10 | 2004–2021 ↑↑ | 3.42 | 0.89 | 0.94 | 5.23E-09 |
T35 (35 ≤ x < 40) | 1975–2004 ↑ | 0.41 | 0.75 | 0.86 | 7.83E-10 | 2004–2021 ↑↑ | 3.06 | 0.91 | 0.95 | 1.26E-09 |
T40 (40 ≤ x < 45) | 1975–2006 ↑ | 0.41 | 0.69 | 0.83 | 3.69E-09 | 2006–2021 ↑↑ | 2.65 | 0.81 | 0.90 | 2.08E-06 |
T45 (45 ≤ x < 50) | 1975–2006 ↑ | 0.36 | 0.66 | 0.81 | 1.53E-08 | 2006–2021 ↑↑ | 2.83 | 0.90 | 0.95 | 1.55E-08 |
T50 (50 ≤ x < 75) | 1975–2006 ↑ | 0.32 | 0.75 | 0.87 | 1.60E-10 | 2006–2021 ↑↑ | 2.82 | 0.88 | 0.94 | 6.96E-08 |
T75 (75 ≤ x < 100) | 1980–2006 ↑ | 0.16 | 0.37 | 0.61 | 7.34E-04 | 2006–2021 ↑↑ | 2.33 | 0.93 | 0.96 | 2.71E-09 |
T100 (100 ≤ x < 500) | 1980–2006 ↑ | 0.11 | 0.23 | 0.48 | 1.19E-02 | 2006–2021 ↑↑ | 2.02 | 0.78 | 0.88 | 6.81E-06 |
T500 (x ≥ 500) | 1980–2021 ↑ | 0.09 | 0.56 | 0.75 | 1.53E-08 | – | – | – | – | – |
- The slope is the most important information that was shown in bold
- The letter “T” in abbreviations “T0, T1, etc.” stands for “threshold” applied to FPE values. Further, the curve of the number of new genes in the respective FPE range as a function of the year (see Fig. 2) is analyzed with linear regression methods. The trend of changes is generally identified through two phases, i. e. Phase 1 and Phase 2. The slopes, R2, ρ and P-value in time intervals of Phase 1 and Phase 2 are listed based on linear regression model yi ~ C + b.xi; where yi = total number of new genes reaching the specific FPE threshold at year i; xi = year i; b is the slope and C is intercept. The slope (b) indicates the rate increase/decrease of the total number of new genes reaching a specific FPE score threshold throughout the years. A positive slope indicates that, as a trend, the total number of new genes reaching a specific FPE score threshold is larger than the previous year (or from year to year); a negative slope indicates otherwise. ρ is the linear correlation between the total number of new genes reaching a specific FPE score threshold and year. R2 is the square of correlation or the goodness of fit of the linear regression. P-value is the statistical significance of the slope. The total number of genes reaching the specific FPE score threshold can then be estimated by: Ni ~ N(i-1) + yi; where Ni and N(i-1) = total number of genes reaching the specific FPE score threshold at year i and (i-1) respectively. The symbol ↑ indicates growing trend, whereas the symbol ↓ indicates declining trend. The symbol ↑↑ indicates accelerating growth trend