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Fig. 4 | Biology Direct

Fig. 4

From: About the dark corners in the gene function space of Escherichia coli remaining without illumination by scientific literature

Fig. 4

Heatmap of pairwise Jaccard Index among the 45 GFs with significantly associated GFs. The Jaccard Index represents the extend of overlap between the associated GFs. Higher Jaccard Index (closer to 1 or in red color) means higher overlap of the associated GFs between two GFs, which could suggest the two GFs could be closely related. We highlight three clusters with at least three GFs sharing common associated GFs. These clusters contain GF_29643[b4730/yahV], GF_4841 [b1472/yddL] and GF_8394 [b1392/paaE] (cluster I), GF_15208 [b4778/yecV], GF_801 [b4615/yibV], GF_8481 [b4776/ynfU] and GF_10326 [b4749/ynfR] (cluster II) and GF_9576 [b2642/yfjW], GF_9575 [b2629/yfjM], GF_10334 [b2638/yfjU], GF_2127 [b4729/ykgV], GF_29089 [b4780/yodE] and GF_29267 [b1567/ydfW] (cluster III). The cluster II genes belong to Qin and rac cryptic prophages, whereas cluster III genes are known to be part of cryptic prophages CP4-57 and CP4-6. Cryptic prophages have been suggested to play an important role in bacterial cell physiology including bacterial cell growth, biofilm formation and environmental stress resistance [60]

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