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Table 1 The enriched key pathways and identified targets

From: A functional reference map of the RNF8 interactome in cancer

Pathway

Members

Epigenetic regulation of gene expression

HDAC1; SIRT1; UBTF; CHD4; GTF2H3; DNMT1; RBBP4; POLR2E; POLR1A; DEK; MBD3; MYBBP1A; GTF2H4; MTA2

Chromatin organization

HDAC1; KDM1A; WDR5; RUVBL1; CHD4; HCFC1; MTA2; NFKB2; RUVBL2; PRMT5; MORF4L1; ACTL6A; MBD3; PBRM1; SMARCA2; RBBP4; MORF4L2; WDR77; KDM5A

DNA repair

PCNA; POLR2E; DDB1; TP53; RAD51; GTF2H3; TCEA1; POLR2A; COPS5; APEX1; CDK2; PARP1; TP53BP1; ACTL6A; POLR2C; ASCC3; RUVBL1; GTF2H4; XRCC5; XRCC6

TNFalpha

HDAC1; TXN; DDX3X; LRPPRC; POLR1A; MCM7; YWHAB; MAPK1; ACTL6A; CDK9; CCNT1; FLNA; PSMC2; NFKB2

Oncogenic MAPK signaling

PHB; MACF1; FXR1; MAPK1; SND1; YWHAB; MEF2C; PPP2CA

TGF_beta_Receptor

HDAC1; DAXX; TP53; COPS5; MEF2C; CDK2; MAPK1; EWSR1

C-MYC pathway

PPP2CA; RUVBL1; ACTL6A; RUVBL2

SUMOylation

PCNA; TP53; NUP98; PARP1; HNRNPK; TP53BP1; HNRNPC; RNF2

p53 signaling pathway

PCNA; CDK2; TP53

mRNA splicing

SRSF1; SRSF2; POLR2E; POLR2A; POLR2C; YBX1; PRPF6……

Cell cycle

HDAC1; AHCTF1; RUVBL1; TP53; RUVBL2; PPP2CA; NUP98; RBBP4; MCM7; PCNA; CDK2; MAPK1; MCM3; TERF2IP; YWHAB; TP53BP1; NPM1