Table 2 Mutational rate of most frequently altered genes in CRC in HM, HM-like and non-HM group
Genes | Pathway | HM (%) | HM-like (%) | Non-HM (%) | P value |
|---|---|---|---|---|---|
APC | WNT signaling | 49 | 59 | 84 | *** |
AMER1 | WNT signaling | 27 | 15 | 9 | *** |
CTNNB1 | WNT signaling | 24 | 12 | 3 | *** |
TCF7L2 | WNT signaling | 24 | 0 | 7 | *** |
FBXW7 | WNT signaling | 40 | 32 | 11 | *** |
ARID1A | WNT signaling | 45 | 5 | 6 | *** |
SOX9 | WNT signaling | 15 | 27 | 11 | * |
TGFBR2 | TGF-β signaling | 12 | 7 | 1 | NS |
ACVR2A | TGF-β signaling | 37 | 15 | 1 | ** |
SMAD4 | TGF-β signaling | 15 | 17 | 12 | NS |
PIK3CA | PIK3 signaling | 40 | 41 | 21 | *** |
PTEN | PIK3 signaling | 22 | 10 | 3 | ** |
FAT4 | Hippo signaling pathway | 76 | 24 | 15 | *** |
ERBB2 | MAPK signaling | 15 | 5 | 2 | *** |
ERBB3 | MAPK signaling | 22 | 5 | 2 | *** |
KRAS | MAPK signaling | 26 | 59 | 41 | *** |
NRAS | MAPK signaling | 4 | 7 | 7 | NS |
BRAF | MAPK signaling | 62 | 12 | 3 | *** |
ATM | DNA damage response | 50 | 10 | 7 | *** |
TP53 | DNA damage response | 29 | 15 | 69 | *** |
LRP1B | Membrane trafficking | 53 | 5 | 13 | *** |
KMT2D | Histone methyl transferase | 64 | 15 | 3 | *** |