Fig. 3

Cancer-specific survival (CSS). A CSS after diagnosis of castration-resistant prostate cancer (CRPC) was significantly prolonged (P = 0.03) by 32.7 months in patients who received aHyC (red, 82.2 months) compared with patients in the documented control group who did not receive aHyC (blue, 49.5 months). B CSS was further compared only in patients with non-metastatic (M0) CRPC. Median CSS survival was not reached in patients who received aHyC (red line), and it was significantly shorter (P = 0.03) in patients in the documented control group who did not receive aHyC (blue line, 48.3 months). Black dots on the lines represent censored events of specific survival. The common starting point for both groups of patients was the diagnosis of CRPC; cut-off date was 30 September 2021. The tables below the graphs show the number and proportion of patients in both groups who are still at risk at individual time points on the graphs. NA, median value not yet reached; M0, non-metastatic CRPC