From: The p53 family member p73 in the regulation of cell stress response
Cancer | Changes of p73 isoform expression | Conclusions | References |
---|---|---|---|
NSLC | p73↑ | Total p73 does not predict prognosis | [10] |
NSLC | DNp73↑ | DNp73 is associated with poor prognosis | [11] |
Breast | p73↓ | Upregulation is associated with lower pathological grade | [13] |
Breast | p73↑ in 27% | Upregulation is association with higher pathological grade | [12] |
Breast | p73↑ in 38% alpha, gamma, delta epsilon and phi isoforms detected | p73 does not have a tumor suppressor role | [5] |
Esophagus | DNp73↑ in 60% | Leads to b-catenin/TCF activation | [14] |
Gliomas | p73↑ ependymomas and pilocytic astrocytomas | P73 does not influence p21 and MDM2 expression | [15] |
Low grade gliomas | DNp73↑, TAp73↑, DeltaEx2-3↑ | DeltaEx2-3 upregulation predicts progression | [16] |
High grade gliomas | TAp73↑, DNp73↓ | TAp73 is upregulated in high grade gliomas | [17] |
Glioblastomas | DNp73↑, TAp73↓ by PCR | 13 GBM samples examined by IB | [21] |
Cervical | p73↑ | Higher p73 protein is associated with better survival | [22] |