Fig. 7

in the left side of the figure the two clusters (red and green) identified on the basis of the contact network analysis applied to the 4kq8 pdb file are reported (the heme group is also shown in blue). The G-helix has been highlighted by a red dot cloud. On the right side, the same structure is reported together with residue R264 (blue, VDW) and those aminoacids (purple, VDW) which form the access channel for the substrate androstenedione (according to Sgrignani and Magistrato, 2012) and the heme group (in red). The black line in both pictures marks the frontier of the two clusters