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Fig. 2 | Biology Direct

Fig. 2

From: COVID-19 and iron dysregulation: distant sequence similarity between hepcidin and the novel coronavirus spike glycoprotein

Fig. 2

Comparison of the core hepcidin-like motif among the seven known coronavirus human infection-causing strains. Following the alignment presented in Fig. 1a, the core similarity motif, corresponding to the length of the mature human hepcidin sequence, is shown in an alignment containing the spike protein cytoplasmic domain of the four mild/asymptomatic human coronavirus strains and the three severe-disease-associated strains. Hepcidin sequences from the previous figure appear on the last four lines. The alignment color scheme is the same as in Fig. 1. Focusing on the region between the two black arrows, fewer similar residues could be observed between the group of mild/asymptomatic coronavirus strains and the MERS/SARS-CoV strains. One such residue that can act to distinguish the groups is indicated with a red arrow. The accession numbers of the sequences shown, in order of appearance, are: (1) ARU07601.1, (2) AFD98827.1, (3) AZS52618.1, (4) AXX83351.1, (5) AWH65954.1, (6) NP_828851.1, (7) YP_009724390.1, (8) ANA96027.1, (9) XP_003965681.1, (10) XP_029694670.1, (11) ENSRFET00010014064.1 and (12) NP_066998.1. The table presenting the amino acid identity and conservation for the sequences in the aligned region shows the values in percentage points, with the residue conservation values appearing in brackets

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