Fig. 2

Risk groups for neuroblastoma patients. Depending on ploidy, TERT expression, telomerase elongation, ZNF281/ZNF143 expression, Chr17p or Chr1p deletions, neuroblastoma patients can be stratified into distinct sub-groups with distinct prognostic outcome. Therefore, the molecular identification of these markers is pivotal to define the most appropriate therapy for individual patient. For example, patients with Chr17p defect and impaired TRIM37 may be specifically selected for using PLK4 inhibitors, that would be otherwise ineffective in other patients