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Fig. 2 | Biology Direct

Fig. 2

From: Ablation of Fam20c causes amelogenesis imperfecta via inhibiting Smad dependent BMP signaling pathway

Fig. 2

Histological analysis of the enamel defects in the Sox2-Cre;Fam20Cfl/fl mice. A and B, photographs of the mandibular molars of 7-week-old Fam20cfl/fl and Sox2-Cre;Fam20cfl/fl mice. C and D, photographs of the mandibular incisors of 7-week-old Fam20cfl/fl and Sox2-Cre;Fam20cfl/fl mice. E, plain x-ray images of the mandibles of 7-week-old Fam20cfl/fl (the picture above)and Sox2-Cre;Fam20cfl/fl (the picture below)mice. F and G are the reconstructed trans-axial μCT images for molar and incisor enamel. The blue arrows in E, F and G indicate the enamel of first molars. The yellow arrow in E shows the ectopic calcifications in the Sox2-Cre;Fam20cfl/fl mice. The red arrow in G shows the malformed enamel in incisors of the Sox2-Cre;Fam20cfl/fl mice. H and I, H&E staining of the sagittal sections of the mandibular incisors of 3-day-old Fam20cfl/fl and Sox2-Cre;Fam20cfl/fl mice. h1, h2, i1 and i2 are the higher magnification views of the presecretory ameloblasts in red boxes and the secretory ameloblasts in black boxes in H and I, respectively. In the Fam20cfl/fl mice, Tomes’ processes (pointed by black arrow in h2) were clearly visible, whereas they were lost in the Sox2-Cre;Fam20cfl/fl mice (i2). Scale bars: 200 μm in A-D, F and G; 1 mm in E; 500 μm in H and I; 20 μm in h1, h2, i1 and i2

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