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Fig. 2 | Biology Direct

Fig. 2

From: Structural modelling of the lumenal domain of human GPAA1, the metallo-peptide synthetase subunit of the transamidase complex, reveals zinc-binding mode and two flaps surrounding the active site

Fig. 2

The model substrate for GPAA1 imitating a peptide bond between the ω-site and the ethanolamine. We show the structure of the tentative peptide (PEP: di-alanine ethylamine) together with its parameterization. The PEP is coordinated to one Zn via the carbonyl oxygen of the second alanine residue. The mimicked peptide bond formed between the ω-site and the phosphor-ethanolamine moiety is shown by a black arrow (compare also with Figure 2 in reference [23]). For clarity, hydrogen atoms are hidden, and partial charges are shown only for the heavy atoms

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Biology Direct

ISSN: 1745-6150

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