Table 3 Circuits with different effects on angiogenesis
Circuit (Pathway and effector protein) | Status | FDR p-value | GO ID | GO Definition |
|---|---|---|---|---|
Apoptosis: FASLG | DOWN | 1.44E-22 | GO:0016525 | negative regulation of angiogenesis |
PI3K-Akt signaling pathway: FASLG | DOWN | 1.18E-21 | GO:0016525 | negative regulation of angiogenesis |
p53 signaling pathway: THBS1 | UP | 4.43E-09 | GO:0016525 | negative regulation of angiogenesis |
cGMP-PKG signaling pathway: GTF2I | DOWN | 3.40E-06 | GO:0016525 | negative regulation of angiogenesis |
HIF-1 signaling pathway: TEK | DOWN | 8.85E-27 | GO:0045766 | positive regulation of angiogenesis |
HIF-1 signaling pathway: VEGFA | DOWN | 2.20E-25 | GO:0045766 | positive regulation of angiogenesis |
NF-kappa B signaling pathway: PLCG1 | DOWN | 3.62E-17 | GO:0045766 | positive regulation of angiogenesis |