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Fig. 1 | Biology Direct

Fig. 1

From: Models of cell signaling uncover molecular mechanisms of high-risk neuroblastoma and predict disease outcome

Fig. 1

Three signaling circuits ending in the proteins CCL19, CCL21 and GADD45B highlighted within the whole NF-kappa B signaling pathway. The circuits are significantly deactivated in patients with MYCN amplification when compared to patients without such biomarker. The results and the representation have been obtained with the program HiPathia [5]. Blue and red nodes indicate genes downregulated and upregulated, respectively. Blue arrows depict the circuits in which signal transduction is inhibited

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Biology Direct

ISSN: 1745-6150

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