Skip to main content

Advertisement

Table 1 Zero-frame observed/expected (obs/exp) synonymous substitution ratios and corresponding p-values for the TF region

From: ASXL gain-of-function truncation mutants: defective and dysregulated forms of a natural ribosomal frameshifting product?

Gene Taxon Synonymous site conservation
obs/exp p-value
ASXL1 mammals 0.33 3.3 × 10−82
  sauropsids 0.55 4.4 × 10−29
  amphibians 0.43 6.3 × 10−19
  tetrapods 0.43 4.8 × 10−121
  teleosts 0.52 3.2 × 10−49
ASXL2 mammals 0.68 7.6 × 10−22
  sauropsids 0.86 5.7 × 10−3
  amphibians 0.75 6.0 × 10−4
  tetrapods 0.74 1.3 × 10−22
  1. Note that these p-values are for the entire TF ORF and therefore can be lower than the 25-codon sliding window p-values of Fig. 3 and Additional file 1: Fig. S2