Fig. 8

Comparing the administration of high-drug doses separated by drug-free periods with the continuous delivery of relatively low-drug doses. Sample dynamics of the total number of cells ρ(t) (panel b) and the average phenotypic state μ(t) (panel c) for the schedules of drug administration presented in panel (a). The red lines refer to the delivery of the drug dose equivalent to the LC₉₀ for 4 days beginning on days 1, 8, 15, 22, 29, 36, 43, 50, 57, 64, 71 and 80, whereas the blue lines refer to the constant delivery of the drug dose equivalent to the the LC₃₀. The values of the model parameters are as in Table 1, and the initial condition corresponds to the equilibrium population density for c(·)=0 [i.e., the population density \(\overline {n}(x)\) of Eq. (11)]