Table 1 Model parameters for colon/intestinal crypts
Parameter | Estimated value | Ref. | Simulations |
|---|---|---|---|
n: height of human colon crypt (number of cells in one column of crypt) | 80 | [53] | varied (2–80) |
n: height of murine intestinal crypt (number of cells in one column of crypt) | 25 | [33] | |
σ: probability of symmetric division | 16 % in epidermis, | [4] | varied (0–1) |
50 % for intestine, 100 % in germline cells | |||
u: mutation rate | 10−7 in normal cells to 10−2 in the case of chromosomal instability | [68] | u 1 varied from 0.0005 to 0.01 |
u 2 varied from 0.0001 to 0.02 |