Fig. 3
From: Should tissue structure suppress or amplify selection to minimize cancer risk?
Fixation probability of two consecutive mutations on the directed line, a suppressor of selection (red), and the well-mixed population (black) of size N=10. This fixation probability is plotted against the fitness of the first mutation. From top to bottom we show an advantageous second mutation (r 2=1.05), a neutral (r 2=1) and a disadvantageous (r 2=0.95) second mutation. The shaded regions show the fitness values for which the fixation probability of the double mutations is higher on the directed line than in the well-mixed population