Fig. 5

Proteins with multiple regions covering multiple cancer types. Symmetrically positioned boxes represent structural/functional protein units: grey – signal sequence, black – transmembrane region, various colors – domains (red = catalytic domains, blue = all other domains, with abbreviated names written in the box). Boxes above the line represent significantly mutated regions. Colors denote dominant mutation types: black – missense, red – deletions, blue – insertions. Regions are flagged with dominant cancer types together with the p-value of the region. GIST – Gastrointestinal stromal tumor, AML – Acute Myeloid Leukemia, CML – Chronic Myeloid Leukemia. All examples feature multiple regions involved in the same cancer types (a) or multiple cancer-specific regions (b)