Fig. 7

The progeny of WT and Vav1-Cre ^+/− Ccnd1 ^4-5 flox ^+/+ LSKs in BM reconstituted chimeras. Lethally irradiated (1,700 rad) CD45.1⁺ CD45.2⁺ Rag2⁻ mice were injected i.v. with equal numbers (2,500) of LSKs from CD45.1⁺ WT and CD45.2⁺ Ccnd1 ^4-5 flox ^+/+ mice, expressing the Cre recombinase under the Vav1 promoter (Vav cells), and studied two weeks after BM transfer. Upper graphs show WT and lower graphs Vav cells (a). B220⁺ BM cells (b). TN thymocytes. Results are from two independent experiments