Fig. 5

Division rates of hematopoietic lineage cells from Ccnd1 ^Δ1-3 mice. Results show BrdU incorporation in different cell types, defined at the top of each column. In thymocytes and bone marrow cells, BrdU incorporation was evaluated after a 2 h pulse. In peripheral T and B cells, BrdU incorporation was studied in mice receiving 2 BrdU injections/day spaced by twelve hours during three days. Barriers for positive cells were established in the same populations from mice that were not injected with BrdU, labeled simultaneously. Results are from one experiment out of 4 giving the same results. Please note: Since each mouse must be studied individually we could not evaluate BrdU incorporation in CLP or LSKs, which are too rare to allow identification of BrdU labeling in individual mice