Skip to main content

Advertisement

Table 1 Dimensionless parameter values of our full model

From: Onset, timing, and exposure therapy of stress disorders: mechanistic insight from a mathematical model of oscillating neuroendocrine dynamics

Parameter Value Source and Ref. Description
n 5 Assumed Hill coefficient in upregulation function g c (c)
\(\bar {c}_{\infty }\) 0.2 Estimated from [22] Baseline stored CRH level
b 0.6 Estimated from [22] Relates cortisol to stored CRH level
k Undetermined · Relates stored CRH to CRH release rate
μ c Undetermined · Basal CRH release rate
q 0 Undetermined · Maximum CRH release rate
\(q_{1}^{-1}\) Undetermined · Circulating CRH for half-maximum self-upregulation
q 2 1.8 Estimated from [21] Ratio of CRH and cortisol decay rates
\(p_{2}^{-1}\) 0.067 \(p_{2}^{-1}\) [13] (o r)-complex level for half-maximum feedback
p 3 7.2 p 3 [13] Ratio of ACTH and cortisol decay rates
p 4 0.05 p 4 [13] (o r)-complex level for half-maximum upregulation
p 5 0.11 p 5 [13] Basal GR production rate by pituitary
p 6 2.9 p 6 [13] Ratio of GR and cortisol decay rates
t c 69.3 Assumed CRH biosynthesis timescale
t d 1.44 τ” [13] Delay in ACTH-activated cortisol release