Skip to main content

Table 1 Dimensionless parameter values of our full model

From: Onset, timing, and exposure therapy of stress disorders: mechanistic insight from a mathematical model of oscillating neuroendocrine dynamics

Parameter

Value

Source and Ref.

Description

n

5

Assumed

Hill coefficient in upregulation function g c (c)

\(\bar {c}_{\infty }\)

0.2

Estimated from [22]

Baseline stored CRH level

b

0.6

Estimated from [22]

Relates cortisol to stored CRH level

k

Undetermined

·

Relates stored CRH to CRH release rate

ÎĽ c

Undetermined

·

Basal CRH release rate

q 0

Undetermined

·

Maximum CRH release rate

\(q_{1}^{-1}\)

Undetermined

·

Circulating CRH for half-maximum self-upregulation

q 2

1.8

Estimated from [21]

Ratio of CRH and cortisol decay rates

\(p_{2}^{-1}\)

0.067

\(p_{2}^{-1}\) [13]

(o r)-complex level for half-maximum feedback

p 3

7.2

p 3 [13]

Ratio of ACTH and cortisol decay rates

p 4

0.05

p 4 [13]

(o r)-complex level for half-maximum upregulation

p 5

0.11

p 5 [13]

Basal GR production rate by pituitary

p 6

2.9

p 6 [13]

Ratio of GR and cortisol decay rates

t c

69.3

Assumed

CRH biosynthesis timescale

t d

1.44

“ τ” [13]

Delay in ACTH-activated cortisol release