Parameter | Value | Source and Ref. | Description |
---|---|---|---|
n | 5 | Assumed | Hill coefficient in upregulation function g c (c) |
\(\bar {c}_{\infty }\) | 0.2 | Estimated from [22] | Baseline stored CRH level |
b | 0.6 | Estimated from [22] | Relates cortisol to stored CRH level |
k | Undetermined | · | Relates stored CRH to CRH release rate |
μ c | Undetermined | · | Basal CRH release rate |
q 0 | Undetermined | · | Maximum CRH release rate |
\(q_{1}^{-1}\) | Undetermined | · | Circulating CRH for half-maximum self-upregulation |
q 2 | 1.8 | Estimated from [21] | Ratio of CRH and cortisol decay rates |
\(p_{2}^{-1}\) | 0.067 | \(p_{2}^{-1}\) [13] | (o r)-complex level for half-maximum feedback |
p 3 | 7.2 | p 3 [13] | Ratio of ACTH and cortisol decay rates |
p 4 | 0.05 | p 4 [13] | (o r)-complex level for half-maximum upregulation |
p 5 | 0.11 | p 5 [13] | Basal GR production rate by pituitary |
p 6 | 2.9 | p 6 [13] | Ratio of GR and cortisol decay rates |
t c | 69.3 | Assumed | CRH biosynthesis timescale |
t d | 1.44 | “ τ” [13] | Delay in ACTH-activated cortisol release |