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Table 1 RC Details on significant complexes differentiating normal and cancer phenotypes

From: Quantitative proteomics signature profiling based on network contextualization

CORUM ID

Complex name

Functionalities

qPSP pvalue

298

VEGF transcriptional complex

This complex regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.

0.010

1178

BCOR complex (Ubiquitin E3 ligase)

Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. The BCOR complex contains E3 ligase activity for histone H2A. Monoubiquitylated H2A is present together with the BCOR complex at BCL6 target genes in B cells. This strongly suggests a role of BCOR as regulator of BCL6, a sequence-specific transcriptional repressor, that probably plays an important role in lymphomagenesis.

0.010

36

AP1 adaptor complex

This adaptor-related complex participates in a transport step different from that of AP-1. It may function at some trafficking step in the complex pathways between the TGN and the cell surface.

0.010

144

Gamma-BAR-AP1 complex

Protein targeting and endocytosis

0.012

5380

TRBP containing complex

Translation regulation

0.0016

5268

TNF-alpha/NF-kappa B signaling complex 7

Cytokine activity

0.02

1193

Rap1 complex

DNA repair; telomere maintenance

0

193

PA700-20S-PA28 complex

Proteasomal degradation

0

1332

Large Drosha complex

RNA processing

0.0001

5177

Polycystin-1 multiprotein complex

Kidney tissue differentiation

0.021

2318

ITGA6-ITGB4-Laminin10/12 complex

Cell adhesions

0.0001

191

20S proteasome

proteasomal degradation

0

194

PA28gamma-20S proteasome

proteasomal degradation

0

5179

NCOA6-DNA-PK-Ku-PARP1 complex

DNA repair

0

5266

TNF-alpha/NF-kappa B signaling complex 6

Cyokine activity

0