From: Quantitative proteomics signature profiling based on network contextualization
CORUM ID | Complex name | Functionalities | qPSP pvalue |
---|---|---|---|
298 | VEGF transcriptional complex | This complex regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. | 0.010 |
1178 | BCOR complex (Ubiquitin E3 ligase) | Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. The BCOR complex contains E3 ligase activity for histone H2A. Monoubiquitylated H2A is present together with the BCOR complex at BCL6 target genes in B cells. This strongly suggests a role of BCOR as regulator of BCL6, a sequence-specific transcriptional repressor, that probably plays an important role in lymphomagenesis. | 0.010 |
36 | AP1 adaptor complex | This adaptor-related complex participates in a transport step different from that of AP-1. It may function at some trafficking step in the complex pathways between the TGN and the cell surface. | 0.010 |
144 | Gamma-BAR-AP1 complex | Protein targeting and endocytosis | 0.012 |
5380 | TRBP containing complex | Translation regulation | 0.0016 |
5268 | TNF-alpha/NF-kappa B signaling complex 7 | Cytokine activity | 0.02 |
1193 | Rap1 complex | DNA repair; telomere maintenance | 0 |
193 | PA700-20S-PA28 complex | Proteasomal degradation | 0 |
1332 | Large Drosha complex | RNA processing | 0.0001 |
5177 | Polycystin-1 multiprotein complex | Kidney tissue differentiation | 0.021 |
2318 | ITGA6-ITGB4-Laminin10/12 complex | Cell adhesions | 0.0001 |
191 | 20S proteasome | proteasomal degradation | 0 |
194 | PA28gamma-20S proteasome | proteasomal degradation | 0 |
5179 | NCOA6-DNA-PK-Ku-PARP1 complex | DNA repair | 0 |
5266 | TNF-alpha/NF-kappa B signaling complex 6 | Cyokine activity | 0 |