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Table 1 Contingency table to validate the assumption that DDLs significantly share disease-related genes or drugs

From: The human disease network in terms of dysfunctional regulatory mechanisms

  

Disease pairs correlated to known disease genes or drugs

 
  

DDLs

Non-DDLs

Total

P-value of Fisher’s Exact test

Disease pairs sharing disease genes

Significant

910 (81 %)

2911 (78 %)

3821

0.009085a

Non-significant

209 (19 %)

821 (22 %)

1030

 
 

Total

1119

3732

  

Disease pairs sharing disease drugs

Significant

348 (47 %)

1095 (42 %)

1443

0.02307a

Non-significant

397 (53 %)

1481 (58 %)

1881

 
 

Total

745

2576

  
  1. adenotes statistic significance by one-sided Fisher’s Exact test (p < 0.05)