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Fig. 4 | Biology Direct

Fig. 4

From: Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer

Fig. 4

Validation of synthetic lethal interactions against GARP essentiality scores from cell line screens [31, 32]. The left-hand plots compare the ranges for GARP scores of our predicted genes B (deleted/downregulated) with that of the entire set (~16000) of profiled genes. While it is difficult to directly compare the two ranges because of the difference in the number of genes in them, for majority of the cell lines the gene B at the 25th percentile had lower GARP scores than the corresponding gene from the entire profiled set. By χ2 test, genes B were significantly enriched (p < 10−5) with the top-quartile essential genes in these cell lines. The right-hand plots show GE ranks vs ME ranks for genes B in cell lines that are deficient in genes A: a BRCA1, b BRCA2, and c PTEN

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