Fig. 2

The schematic build-up of the webserver and its service. Here we summarize the workflow of the web server. User requests are inserted into a database storing jobs. A Python script periodically checks if new request is inserted. If the submission does not contains topology, sequence is submitted to the CCTOP web service. After completion, sequence and topology are delegated to the TMFoldRec program on our HPC cluster via WSDL, which returns a list of templates ordered by the energy and reliability values