The human transmembrane proteome

Biology Direct

Table 3 Topology prediction results on the structure benchmark set

	HMMTOP^a	Membrain	MEMSAT-SVM	Octopus	Philius	Phobius	Pro	Prodiv	Scampi-Msa	TMHMM	TOPCONS	CCTOP^a
Sens/res	0.97	0.99	0.96	0.97	0.96	0.97	0.9	0.97	0.99	0.94	0.97	0.99
Spec/res	0.97	0.94	0.99	0.98	0.98	0.97	0.98	0.97	0.98	0.99	0.98	0.99
MCC/res	0.97	0.96	0.97	0.97	0.97	0.97	0.94	0.97	0.98	0.96	0.96	0.99
Acc _Tpg /prot	84	76	80	83	81	79	66	82	89	76	78	93
Acc _Top /prot	81	0	68	82	74	77	51	67	88	70	76	92

Prediction accuracies of the various topology prediction methods on the structure benchmark set. Sens/res, Spec/res, and MCC/res mean per-residue sensitivity, specificity, and Matthew correlation coefficient, respectively. Acc_Tpg/prot and Acc_Top/prot mean per/-protein topography and topology accuracies multiplied 100, respectively (^apredictions were made without topological constraints)

ISSN: 1745-6150