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Table 1 Results of the various signal peptide prediction methods on the human benchmark set

From: The human transmembrane proteome

 

Philius

Phobius

SignalP

SPOctopus

TP

204

196

194

168

FP

24

21

14

22

TN

234

237

244

235

FN

12

20

22

49

Sensitivity

0.94

0.91

0.90

0.77

Specificity

0.91

0.92

0.95

0.91

MCC

0.84

0.83

0.85

0.70

  1. TP: number of true positives; FP: number of false positives; TN: number of true negatives; FN: number of false negatives; specificity is TN/(TN + FP); sensitivity is TP/(TP + FN); MCC: Matthew’s Correlation Coeffitient is (TP*TN-FP*FN)/sqrt ((TP + FP)*(TP + FN)*(TN + FP)*(TN + FN))