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Fig. 3 | Biology Direct

Fig. 3

From: Design principles for cancer therapy guided by changes in complexity of protein-protein interaction networks

Fig. 3

Analysis of the Protein-Protein Interaction network for Acute Myeloid Leukemia. Protein-protein interaction network (PPI) for AML was obtained from Kyoto Encyclopedia of Genes and Genomes (KEGG) and converted into the figure present in Panel a using R-script known as KEGGraph. It reveals a complex single component network, which breaks into two separate components by targeted elimination of the connecting FLT3 protein. The effect of simultaneous elimination of NRAS and FLT3 (Panel b) leads not only to break down of the network into two separate components, but also to thinning of the main network

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Biology Direct

ISSN: 1745-6150

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