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Table 4 The simulation results

From: Test on existence of histology subtype-specific prognostic signatures among early stage lung adenocarcinoma and squamous cell carcinoma patients using a Cox-model based filter

  Actual value (frequency %) Barcoded value (frequency %)
AC (β 2 ) SCC (β 2 + β 3 ) AC SCC
A. Simulation 1: a case of mutually exclusive markers for each subtype
Gene1 0 100 0 100
Gene2 0 100 0 52.8
Gene3 100 99.6 97.4 46.2
Gene4 90.6 100 97.8 100
Ave.# of selected genes 18.53 17.82 10.00 9.98
B. Simulation 2: a case of no subtype specific prognostic genes
Gene1 100 100 100 99.8
Gene2 100 100 100 100
Gene3 100 100 100 100
Gene4 100 100 100 100
Ave.# of selected genes 33.57 29.88 27.28 19.26
  1. Note: Frequency represents the percentage of being non-zeros among 500 replicates; Actual value represents the analysis conducted using the actual gene expression values; barcoded value represents the analysis conducted using the barcode expression values.
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