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Table 1 The performance of different prognostic signatures

From: Test on existence of histology subtype-specific prognostic signatures among early stage lung adenocarcinoma and squamous cell carcinoma patients using a Cox-model based filter

Signature (# AC/# SCC) # Low /high risk # of PCs/ % of variance for AC, SCC Accuracy (%) All (AC/SCC) AUC (%) (AC/SCC) p-value (log rank)
A: Using all covariates in the cox model for risk score construction
29-gene (19/24) 91/78 -- 72.19(73.23/69.05) 83.17/79.29 1.74 × 10-9
32-gene (32/12) 87/82 -- 74.56(76.38/69.05) 79.82/79.57 2.74 × 10-13
26-gene (26/0) a1 83/86 -- 62.72 69.96 1.22 × 10-4
26-gene (26/0) b1 88/81 -- 63.31 73.90 9.01 × 10-5
15-gene by Zhu2 90/79 -- 63.31 68.99 1.43 × 10-4
13-gene by Guo2 84/85 -- 63.31 67.55 4.51 × 10-4
B: Using the modified PCA procedure for risk score construction
29-gene (19/24) 86/83 3/96.19, 4/95.75 68.05(70.87/53.19) 76.72/68.26 3.34 × 10-7
32-gene (32/12) 86/83 12/95.75, 7/96.63 65.68(66.93/61.90) 77.18/71.89 2.26 × 10-5
26-gene (26/0) a1 81/88 16/95.76 60.36 66.59 1.22 × 10-3
15-gene2 91/78 3/96.41 60.36 64.04 1.34 × 10-3
13-gene2 91/78 2/96.71 60.36 58.20 1.34 × 10-3
  1. Note: 29-gene signature was obtained using all 6,202 genes under consideration; 32-gene signature was obtained using 1,889 genes with extra barcode-frequency filtering and actual expression values of these genes; 26-gene signature was obtained using the barcode values of those 1,889 genes; 15-gene signature was the one in Zhu’s study [19]; 13-gene signature was the one in Guo’s study [24].
  2. 1Those statistics were computed for all samples pretending AC-specific genes are common prognostic genes for both AC and SCC; a: abbreviates for actual values and b: abbreviates for barcoded values. 2Those are AC/SCC common genes.
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