Test on existence of histology subtype-specific prognostic signatures among early stage lung adenocarcinoma and squamous cell carcinoma patients using a Cox-model based filter

Table 1 The performance of different prognostic signatures

Signature (# AC/# SCC)	# Low /high risk	# of PCs/ % of variance for AC, SCC	Accuracy (%) All (AC/SCC)	AUC (%) (AC/SCC)	p-value (log rank)
A: Using all covariates in the cox model for risk score construction
29-gene (19/24)	91/78	--	72.19(73.23/69.05)	83.17/79.29	1.74 × 10^-9
32-gene (32/12)	87/82	--	74.56(76.38/69.05)	79.82/79.57	2.74 × 10^-13
26-gene (26/0) a¹	83/86	--	62.72	69.96	1.22 × 10^-4
26-gene (26/0) b¹	88/81	--	63.31	73.90	9.01 × 10^-5
15-gene by Zhu²	90/79	--	63.31	68.99	1.43 × 10^-4
13-gene by Guo²	84/85	--	63.31	67.55	4.51 × 10^-4
B: Using the modified PCA procedure for risk score construction
29-gene (19/24)	86/83	3/96.19, 4/95.75	68.05(70.87/53.19)	76.72/68.26	3.34 × 10^-7
32-gene (32/12)	86/83	12/95.75, 7/96.63	65.68(66.93/61.90)	77.18/71.89	2.26 × 10^-5
26-gene (26/0) a¹	81/88	16/95.76	60.36	66.59	1.22 × 10^-3
15-gene²	91/78	3/96.41	60.36	64.04	1.34 × 10^-3
13-gene²	91/78	2/96.71	60.36	58.20	1.34 × 10^-3

Note: 29-gene signature was obtained using all 6,202 genes under consideration; 32-gene signature was obtained using 1,889 genes with extra barcode-frequency filtering and actual expression values of these genes; 26-gene signature was obtained using the barcode values of those 1,889 genes; 15-gene signature was the one in Zhu’s study [19]; 13-gene signature was the one in Guo’s study [24].
¹Those statistics were computed for all samples pretending AC-specific genes are common prognostic genes for both AC and SCC; a: abbreviates for actual values and b: abbreviates for barcoded values. ²Those are AC/SCC common genes.

ISSN: 1745-6150