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Table 2 SDL + INV groups

From: Synthetic lethals in HIV: ways to avoid drug resistance

  

SDL + Inv*

Binding site

Site Volume

Protease

NT

35, 61, 37, 72, 40, 34, 42, 81

40 + 42 + 61

103

12, 14, 19, 21

12 + 14 + 19

82

T

35, 37, 81, 45, 40, 46, 42, 52, 44

  

12, 14, 19, 21

12 + 14 + 19

 

63, 72

  

Reverse Transcriptase

NT

35, 39, 40, 48,43, 44, 210, 215, 4, 29, 42, 1, 45, 113, 212

  

83, 86, 13, 89, 14, 93, 157, 15, 16, 17

13 + 14 + 15 + 86 + 17

243

194, 200, 192, 203, 199, 222

  

243, 226, 245, 240, 259, 262, 263, 268, 266, 265

259 + 262 + 263 + 266

375

6, 9

  

T

394, 395,33, 355, 415, 399, 332, 357, 326, 418, 421, 424, 426

  

199, 197, 203, 200, 204, 207, 210, 211, 43, 39, 212, 110, 157, 48, 44, 4, 113, 215, 184, 42, 40, 1, 151, 218, 219, 185, 45, 152, 222

  

68, 67, 69, 70, 72, 290, 291, 64, 65, 63, 292, 250, 66, 294, 296, 297

63 + 64 + 65 + 66 + 67 + 70 + 72

252

82, 83, 16, 13, 14, 15, 17

13 + 14 + 15 + 17

243

321, 323, 324, 238, 344, 346, 345, 347, 348, 351

  

32, 28, 23, 137, 24, 29, 25

  

166, 169, 173, 170, 174, 177, 192

  

122, 9, 126, 51, 52, 55

  

226, 228

  

243, 245

  

101, 237

  
  1. *at the protein surface and close in space.
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