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Figure 7 | Biology Direct

Figure 7

From: Synthetic lethals in HIV: ways to avoid drug resistance

Figure 7

3D view of the potential target sites. A: The different target sites are shown on a 3D representation of the HIV-1 homodimer (1HSG) PR. The red target is lining a pocket necessary for the opening of the flaps. The blue one in located in the fulcrum of the protein. B: The different target sites are shown on a 3D representation of the HIV-1 homodimer (DLO1) RT. The red and the yellow targets are lining a pocket necessary for docking DNA. The color residues are those constituting of SDL groups and forming a binding site according to the results given by the Q-siteFinder software. The 3D molecules of the A and B panel were built by pymol software [43].

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