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Figure 4 | Biology Direct

Figure 4

From: A new ensemble coevolution system for detecting HIV-1 protein coevolution

Figure 4

Prediction similarity of sequence-based methods and method clustering. (A) Jaccard and association coefficients between the L top-ranked couplings predicted by 28 sequence-based methods. (B) Hierarchical clustering analysis of Jaccard (bottom) and association (left) coefficients between the 28 sequence-based methods. The heat-map distinguishes the smallest (green) and highest (red) coefficients between the 28 sequence-based methods. (C) Four method clusters identified commonly by the two clustering trees in (B). The arrows connect four methods (CMPro, NCPS, PhyCMAP, RCW) integrated in CNPR. Methods designed based on mutual information are colored in green, phylogenetics in grey, machine learning in pink.

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