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Table 1 Moonlighting proteins identified in E. coli

From: Genome-scale identification and characterization of moonlighting proteins

Proteinname/uniprot ID/gene ID First function Additional functions Category a) Ref.
b0118/P36683/AcnB Aconitate hydratase Post-transcriptional regulation; mRNA binding I [27]
b1019/P31545/EfeB Peroxidase on guaiacol Iron assimilation from heme; response to DNA damage stimulas I [43]
b1276/P25516/AcnA Aconitate hydratase Post-transcriptional regulation; mRNA binding I [27]
b1967/P31658/HchA Molecular chaperone Glyoxalase activity I [44]
b3183/P42641/ObgE GTPase Role in ribosome biogenesis I [45],[46]
b4151/P0A8Q3/FrdD Membrane bound respiratory protein (anaerobic condition) Role in bacterial flagellar switch (aerobic conditions) I [47]
b4152/P0A8Q0/FrdC Membrane bound respiratory protein (anaerobic condition) Role in bacterial flagellar switch (aerobic conditions) I [47]
b4153/P0AC47/FrdB Membrane bound respiratory protein (anaerobic condition) Role in bacterial flagellar switch (aerobic conditions) I [47]
b4154/P00363/FrdA Membrane bound respiratory protein (anaerobic condition) Role in bacterial flagellar switch (aerobic conditions) I [47]
b4179/P21499/Rnr Helicase RNase I [48]
b4260/P68767/PepA†b) Plasmid recombination Peptide catabolic process; DNA binding/transcriptional control I [49]
b0161/P0C0V0/DegP Chaperone Proteolysis II [50]
b0509/P77161/GlxR Glyoxylate metabolism Allantoin assimilation; DNA damage response II [51],[52]
b0957/P0A910/OmpA Transport 1. Viral entry 2.DNA damage response II [51],[53]
b1317/P77366/YcjU Carbohydrate metabolism 1. Cell-to-cell plasmid transfer 2. Reduce the lethal effects of stress II [54],[55]
b1710/P06610/BtuE Glutathione peroxidase Non-essential role in vitamin-B12 transport II [56],[57]
b2415/P0AA04/PtsH Phosphocarrier protein essential in sugar transport Positive regulation of glycogen catabolism II [58]
b2552/P24232/Hmp (aerobic condition) Nitric oxide dioxygenase (NOD) (anaerobic condition) Amplifier of superoxide stress, NO and FAD reductase II [59],[60]
b2949/P0A8I1/YqgF Putative Holliday junction resolvase Transcription anti-termination II [61],[62]
b3414/P63020/NfuA Fe-S biogenesis Necessary for the use of extracellular DNA as the sole source of carbon and energy II [63]
b3463/P0A9R7/FtsE Cell division Salt transport by ABC-Transporter II [64]
b3706/P25522/MnmE tRNA modification Regulating glutamate-dependent acid resistance II [65]
b0135/P31058/YadC Cell adhesion Reduce lethal effects of stress III [55]
b0284/P77489/YagR Putative xanthine dehydrogenase DNA damage response III [51]
b0543/P23895/EmrE Multidrug transporter DNA damage response III [51]
b1018/P0AB24/EfeO Involved in Iron uptake Response to lethal antimicrobial and environmental stress III [55]
b2037/P37746/RfbX Putative O-antigen transporter DNA damage response III [51]
b2147/P25889/PreA Pyrimidine base degradation Required for swarming motility III [66]
b2290/P0A959/AlaA Involved in biosynthesis of alanine Response to lethal antimicrobial and environmental stress III [55]
b3191/P64602/MlaB Phospholipid ABC transporter Response to lethal antimicrobial and environmental stress III [55]
b3233/P0A9Q9/Asd Aspartate-semialdehyde dehydrogenase DNA damage response III [51]
b4177/P0A7D4/PurA Adenylosuccinate synthetase DNA damage response III [51]
b4383/P0A6K6/DeoB Phosphopentomutase DNA damage response III [51]
  1. a)Moonlighting proteins are classified into four categories: I, both primary and the secondary functions have clear experimental evidences that they are independent; II, both primary and the secondary functions have experimental evidences but it is not clear if the functions are independent; III, “weak” moonlighting proteins, evidences for the secondary function is from a large scale assay or a phenotypic experiment of mutants and the relationship between the primary and the secondary function is not known. Proteins are sorted by the b number within each category.
  2. b)Proteins included in either MoonProt or MultiTaskDB are indicated with. PepA is included in the MoonProt database. DegP is included in both MoonProt and MultiTaskDB.