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Table 5 Pathway enrichment analysis of M. tuberculosis H37Rv proteins involved in the predicted host-pathogen PPI dataset

From: Stringent homology-based prediction of H. sapiens-M. tuberculosis H37Rv protein-protein interactions

Pathway names

p-value

Metabolic pathways

6.81E-39

tRNA charging pathway

1.46E-18

Biosynthesis of secondary metabolites

1.54E-17

Pyrimidine metabolism

6.72E-10

Purine metabolism

2.25E-09

Aminoacyl-tRNA biosynthesis

6.47E-09

Alanine, aspartate and glutamate metabolism

3.09E-07

Superpathway of histidine, purine, and pyrimidine biosynthesis

3.25E-07

Superpathway of chorismate

1.14E-06

Arginine biosynthesis

1.39E-06

Superpathway of citrulline metabolism

2.13E-06

Tetrapyrrole biosynthesis I

2.13E-06

Tryptophan biosynthesis

2.13E-06

Phenylalanine, tyrosine and tryptophan biosynthesis

2.22E-06

Superpathway of cytosolic glycolysis, pyruvate dehydrogenase and TCA cycle

1.72E-05

Glyceraldehyde 3-phosphate degradation

3.47E-05

Gluconeogenesis I

3.92E-05

Pyrimidine ribonucleotides de novo biosynthesis

3.92E-05

Nucleotide excision repair

3.98E-05

Glycine, serine and threonine metabolism

4.53E-05

  1. This table summarizes the 15 most significantly enriched pathways for M. tuberculosis H37Rv proteins involved in the predicted host-pathogen PPI dataset.