Principle Method | Reference | Software |
---|---|---|
Average of single-gene statistics | [79] | sigPathway |
Linear Model Toolset for GSEA | [80] | GSEAlm |
SAM-GS | [81] | Â |
Globaltest | [82] | globaltest |
GlobalANCOVA | [83] | GlobalAncova |
Hotelling’s T2 | PCOT2 | |
N-statistic | [88] | cramer |
RCMAT | [89] | Â |
Non-linear tests for identifying differentially expressed genes or genetic networks | [87] | Â |
Pathway-express | [90] | Â |
Signaling Pathway Impact Analysis | [91] | SPIA (Bioconductor) |
SEPEA | [92] | Â |
PARADIGM | [93] | Â |
Gene set analysis exploiting the topology of a pathway | [94] | IPS (available upon request) |