Thousands of missed genes found in bacterial genomes and their analysis with COMBREX

Biology Direct

Table 2 Examples of missed genes associated with COMBREX phenotype data

Assigned Name	CP001172_orf00556	CP000948_orf05287	CP002071_orf01199
Species containing missed gene	Acinetobacter baumannii AB307-0294	Escherichia coli K-12 substr. DH10B	Helicobacter pylori Sat464
Species containing homologous gene	Escherichia coli ED1a	Escherichia coli K-12 substr. MG1655	Helicobacter pylori 26695
Name of homologous gene	dimethyladenosine transferase	adenylate cyclase (EC 4.6.1.1)	hypothetical protein
Blast E-value	9e-75	0.0	1e-176
Combrex phenotype associations	antibiotic resistance class KsgA	picin sensitivity and triclosan sensitivity	candidate essential gene

Three representative examples of missed genes that are associated with COMBREX phenotype data: “antibiotic resistance”, “antibiotic sensitivity”, or “candidate essential gene”. Note that CP002071_orf01199 is a hypothetical missed gene with BLAST similarity only to hypothetical proteins.

ISSN: 1745-6150