Figure 5
Links between the DUF71 family and B12 salvage. (A) Summary of cobinamide derivative salvage in Bacteria and Archaea; arrows with dotted lines denote multiple steps. (B) Typical examples of physical clustering of DUF71-B12 genes with B12 salvage genes in Archaea and Bacteria. Abbreviations: Pseudo-B12, adenosylpseudocobalamin; Cbi, Cobinamide; AdoCbi, adenosylCbi; AdoCbi-P, AdenosylCbi-phosphate; AdoCby, adenosylcobyric acid; AP; (R)-1-amino-2-propanol; AP-P, AP-phosphate; Thr-P, L-threonine-phosphate; DMB, 5,6-dimethylbenzimidazole; α-AMP-AP, α-adenylate-AP; CobU, ATP:AdoCbi kinase, GTP:AdoCbi-GDP guanylyltransferase; CobY, NTP:AdoCbi-P nucleotidyltransferase; CobA, ATP:co(I)rrinoid adenosyltransferase; aCbiZ, adenosylcobinamide amidohydrolase; bCbiZ, pseudo-B12 amidohydrolase; CbiB, cobyric acid synthetase; CobD, L-threonine phosphate decarboxylase; CobS, cobalamin (5-P) synthase; CobT, 5,6-dimethylbenzimidazole phosphoribosyltransferase; CobC or CobZ, alpha-ribazole-5′-phosphate phosphatase; cobY, adenosylcobinamide-phosphate guanylyltransferase; CbiP, cobyric acid synthase; BtuFCD, cobamide transporter subunits.