Figure 6
From: IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lprmice
Serum creatinine as a function of age in mice of the three MRL/ lpr γ3 heavy chain genotypes. The serum creatinine increased early (by 21 weeks) during the course of disease in +/+ mice (green squares), whereas -/- mice (red circles) exhibited a more gradual course, with levels of serum creatinine significantly less than in +/+ mice at 21 and 26 weeks. The +/- (yellow diamonds) mice followed an intermediate course.