Figure 5
From: IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lprmice
Urinary protein:creatinine ratio as a function of age in mice of the three MRL/ lpr γ3 heavy chain genotypes. All mice, regardless of the γ3 heavy chain genotype, exhibited pathologic and heavy proteinuria throughout the observation period. The mean urinary protein:creatinine ratio exceeded 15 at all time points observed in +/+ mice (green squares), whereas it increased from 4.58 to 21.1 in +/- mice (yellow diamonds) and from 5.5 to 11.9 in -/- mice (red circles).