Figure 8

Representative domain architectures of several nucleic acid-targeting toxin domains: (A) two distinct families of URI nucleases (Tox-URI1 and Tox-URI2), (B) Tox-ComI nuclease, (C) two distinct ParB fold families (Tox-ParB, Tox-ParBL1), (D) two novel JAB families (Tox-JAB-1, Tox-JAB-2). (E) Multiple sequence alignment of the Het-C domain with Zinc-dependent phospholipase C and S1-P1 nuclease, showing their homologous relationship. Conserved catalytic residues are labeled with blue ‘#’. The labeling scheme for domain architectures and alignments, and the coloring scheme and consensus abbreviations are as in Figure 3.