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Table 6 Nine genes highlighted as XLMR candidates by both the annotation and sequence motif method

From: A computational approach to candidate gene prioritization for X-linked mental retardation using annotation-based binary filtering and motif-based linear discriminatory analysis

HGNC symbol

Description

Location

Function

FAM156A

Family with sequence similarity 156, member A

Xp11.23

Function Unknown

FAM156B

Family with sequence similarity 156, member B

Xp11.22

Function Unknown

UXT

Ubiquitously-expressed transcript

Xp11.23-p11.22

Plays a role in facilitating receptor-induced transcriptional activation [83]

TBL1X

Transducin (beta)-like 1X-linked

Xp22.3

Plays an essential role in transcription activation mediated by nuclear receptors [84]

MAGED4

Melanoma antigen family D, 4

Xp11

Mainly tumour cell proliferation [85]

MAGED4B

Melanoma antigen family D, 4B

Xp11

Mainly tumour cell proliferation [85]

ZC4H2

Zinc finger, C4H2 domain containing

Xq11.1

Hepatocellular carcinoma-associated antigen [38]

APLN

Apelin

Xq25

Neuropeptide involved in the regulation of body fluid homeostasis and cardiovascular functions [86]

RAP2C

Member of RAS oncogene family

Xq25

Involved in serum response element mediated gene transcription [64]