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Table 1 Annotation terms identified to be pertinent to XLMR using a literature- and data-mining approach

From: A computational approach to candidate gene prioritization for X-linked mental retardation using annotation-based binary filtering and motif-based linear discriminatory analysis

ANNOTATION TERM CATEGORIES1
Anatomical site Biological Process Phenotype Animal model homology
Developmental Development Seizures Phenotype
Liver Transcription Epilepsy Behaviour/Neurological
Central nervous system Metabolism Acidosis Nervous system related
Respiratory Phosphorylation Microcephaly Embryogenesis
Cerebellum Brain development Tremor  
Kidney    Timing
Hippocampus    Pre-Embryonic
Spinal cord    Embryonic
Cerebral cortex    Fetal
Testis    
Brain stem    Anatomy
Peripheral nerve    2TS8-9 Ectoderm
Cerebrum    TS10-13 Neural Ectoderm
Substantia nigra    TS14-26 CNS
Cardiovascular    
Adrenal gland    
Thyroid    
Ovary    
Amygdala    
Musculoskeletal    
Ganglion    
Hypothalamus    
  1. 1These terms were used to extract gene lists that were compared to all X chromosome genes in a binary filtering process. Annotation terms are divided into four categories based on their ontological classification.
  2. 2TS - Theiller stage: A term used to denote the stage of development of a mouse as described by Theiler in "The House Mouse: Atlas of Mouse Development" (Springer-Verlag, New York, 1989)