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Table 9 Examples of drugs targets sites with resistance in archaea.

From: The origin of a derived superkingdom: how a gram-positive bacterium crossed the desert to become an archaeon

Target Site Example drugs
23s RNA between L22 and L4 Macrolides[106] and PTF inhibitors [105]
RNA Polymerase GE23077[130]
EF-Tu Kirromycin [131]
  1. These drugs bind targets sites present in both bacteria and archaea (or eukaryotes), but with very different affinities. We argue this is a molecular fossil of the unique antibiotic war that resulted in the origin of archaea.