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Table 9 Examples of drugs targets sites with resistance in archaea.

From: The origin of a derived superkingdom: how a gram-positive bacterium crossed the desert to become an archaeon

Target Site

Example drugs

23s RNA between L22 and L4

Macrolides[106] and PTF inhibitors [105]

RNA Polymerase

GE23077[130]

EF-Tu

Kirromycin [131]

  1. These drugs bind targets sites present in both bacteria and archaea (or eukaryotes), but with very different affinities. We argue this is a molecular fossil of the unique antibiotic war that resulted in the origin of archaea.
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Biology Direct

ISSN: 1745-6150

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