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Table 8 Drug targets found across bacteria that were probably not in LACA.

From: The origin of a derived superkingdom: how a gram-positive bacterium crossed the desert to become an archaeon

Target

Example Drug

Alanine Racemase

Cycloserine

Beta-lactamase

Cefoxitin

Hsp90

Geldanamycin

Cytochrome c

Minocycline

DNA gyrase

Trovafloxacin

3-oxoacyl-[acyl-carrier-protein] synthase 1

Cerulenin

Penicillin-binding proteins

Cefoperazone

Peptidoglycan synthetase ftsI

Ertapenem

  1. We argue these proteins were lost in the archaeal ancestor in response to a unique antibiotic warfare scenario. Targets in italics appear to have transferred to archaea after LACA.
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Biology Direct

ISSN: 1745-6150

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