Skip to main content

Table 4 Functional enrichment of fast-evolving and slow-evolving genes in rodents.

From: Nonsynonymous substitution rate (Ka) is a relatively consistent parameter for defining fast-evolving and slow-evolving protein-coding genes

Fast-evolving genes

ID

Category Name

guiniea pig

mouse

rat

MF00250

Serine protease inhibitor

*

*

*

MF00006

Interleukin receptor

 

*

*

BP00117

JAK-STAT cascade

 

*

*

Slow-evolving genes

MF00261

Actin binding cytoskeletal protein

*

*

*

MF00264

Microtubule family cytoskeletal protein

*

*

*

MF00009

Glutamate receptor

*

*

 

MF00008

Ligand-gated ion channel

*

*

 

MF00024

Ion channel

*

*

 

MF00069

Ribonucleoprotein

*

*

 

BP00051

mRNA end-processing and stability

*

  

BP00126

Exocytosis

 

*

*

BP00246

Ectoderm development

 

*

*

BP00137

Protein targeting and localization

 

*

 

MF00052

DNA-directed RNA polymerase

 

*

 

MF00156

Other hydrolase

 

*

 

BP00199

Neurogenesis

 

*

*

BP00133

Nuclear transport

  

*

BP00066

Protein acetylation

  

*

P05911

Angiotensin II-stimulated signaling through G proteins and beta-arrestin

 

*

*

P00007

Axon guidance mediated by semaphorins

 

*

*

P05731

GABA-B receptor II signaling

 

*

 

P05913

Enkephalin release

 

*

 

P00038

JAK/STAT signaling pathway

  

*

P05734

Synaptic vesicle trafficking

  

*

  1. Note: The asterisks depict functional classifications of genes that are significantly enriched based on Fisher's Exact Test after multiple corrections among rodents.