Table 1 Selected common functional categories of fast-evolving genes and/or slow-evolving genes among mammalian genomes and lineages.

Immunity and defense

*

*

*

*

*

*

*

*

*

*

*

*

Biological process unclassified

*

*

*

*

*

*

*

*

*

*

*

*

Immunoglobulin receptor family member

*

*

*

*

*

*

*

*

*

*

*

*

Defense/immunity protein

*

*

*

*

*

*

*

*

*

*

*

*

Molecular function unclassified

*

*

*

*

*

*

*

*

*

*

*

*

Receptor

*

*

*

*

*

*

*

*

*

Cytokine and chemokine mediated signaling pathway

*

*

*

*

*

*

*

*

*

Cytokine receptor

*

*

*

*

*

*

*

*

*

Ligand-mediated signaling

*

*

*

*

*

*

*

*

Other defense and immunity protein

*

*

*

*

*

*

*

*

Natural killer cell mediated immunity

*

*

*

*

*

*

*

T-cell mediated immunity

*

*

*

*

*

*

*

*

B-cell- and antibody-mediated immunity

*

*

*

*

*

*

*

Interleukin

*

*

*

*

*

*

*

Cytokine

*

*

*

*

*

*

*

Slow-evolving genes

Classification

1

2

3

4

5

6

7

8

9

10

11

12

Nucleoside, nucleotide and nucleic acid metabolism

*

*

*

*

*

*

*

*

*

*

*

*

mRNA transcription

*

*

*

*

*

*

*

*

*

*

*

*

Pre-mRNA processing

*

*

*

*

*

*

*

*

*

*

*

*

mRNA splicing

*

*

*

*

*

*

*

*

*

*

*

*

Protein metabolism and modification

*

*

*

*

*

*

*

*

*

*

*

*

Intracellular protein traffic

*

*

*

*

*

*

*

*

*

*

*

*

Nucleic acid binding

*

*

*

*

*

*

*

*

*

*

*

*

mRNA processing factor

*

*

*

*

*

*

*

*

*

*

*

*

mRNA splicing factor

*

*

*

*

*

*

*

*

*

*

*

*

G-protein

*

*

*

*

*

*

*

*

*

*

*

*

Small GTPase

*

*

*

*

*

*

*

*

*

*

*

*

FGF signaling pathway

*

*

*

*

*

*

*

*

*

*

*

*

Ubiquitin proteasome pathway

*

*

*

*

*

*

*

*

*

*

*

*

Protein biosynthesis

*

*

*

*

*

*

*

*

*

*

Ribosomal protein

*

*

*

*

*

*

*

*

*

*

General vesicle transport

*

*

*

*

*

*

*

*

*

*

*

mRNA transcription regulation

*

*

*

*

*

*

*

*

*

*

*

Transcription factor

*

*

*

*

*

*

*

*

*

*

*

Huntington disease

*

*

*

*

*

*

*

*

*

*

*

Select regulatory molecule

*

*

*

*

*

*

*

*

*

*

Translation factor

*

*

*

*

*

*

*

*

*

T cell activation

*

*

*

*

*

*

*

*

*

*

Cell cycle

*

*

*

*

*

*

*

*

*

Mitosis

*

*

*

*

*

*

*

*

Translation initiation factor

*

*

*

*

*

*

*

*

Wnt signaling pathway

*

*

*

*

*

*

*

*

*

PDGF signaling pathway

*

*

*

*

*

*

*

*

*

Other transcription factor

*

*

*

*

*

*

*

Developmental processes

*

*

*

*

*

*

*

Endocytosis

*

*

*

*

*

*

*

*

Protein phosphorylation

*

*

*

*

*

*

*

*

Hedgehog signaling pathway

*

*

*

*

*

*

*

Ionotropic glutamate receptor pathway

*

*

*

*

*

*

*

*

Metabotropic glutamate receptor group III pathway

*

*

*

*

*

*

*

*

Parkinson disease

*

*

*

*

*

*

*

*

B cell activation

*

*

*

*

*

*

*

Angiogenesis

*

*

*

*

*

*

*

*

Ras Pathway

*

*

*

*

*

*

*

*