Skip to main content
Figure 1 | Biology Direct

Figure 1

From: Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution

Figure 1

The tree of life and major steps in cell evolution. Archaebacteria are sisters to eukaryotes and, contrary to widespread assumptions, the youngest bacterial phylum [6, 13]. This tree topology, coupled with extensive losses of posibacterial properties by the ancestral archaebacterium, explains (without lateral gene transfer) how eukaryotes possess a unique combination of properties now seen in archaebacteria, posibacteria and α-proteobacteria. Eukaryote origins in three stages indicated by asterisks probably immediately followed divergence of archaebacteria and eukaryote precursors from the ancestral neomuran. This ancestor arose from a stem actinobacterial posibacterium by a quantum evolutionary shake-up of bacterial organization - the neomuran revolution [6, 12]: surface N-linked glycoproteins replaced murein; ribosomes evolved the signal recognition particle's translational arrest domain; histones replaced DNA gyrase, radically changing DNA replication, repair, and transcription enzymes. The eukaryote depicted is a hypothetical early stage after the origin of nucleus, mitochondrion, cilium, and microtubular skeleton but before distinct anterior and posterior cilia and centriolar and ciliary transformation (anterior cilium young, posterior old: [3]) evolved (probably in the cenancestral eukaryote [9]). Kingdom Chromista was recently expanded to include not only the original groups Heterokonta, Cryptista and Haptophyta, but also Alveolata, Rhizaria and Heliozoa [9], making the name chromalveolates now unnecessary. Excavata now exclude Euglenozoa and comprise just three phyla: the ancestrally aerobic Percolozoa and Loukozoa and the ancestrally anaerobic Metamonada (e.g. Giardia, Trichomonas), which evolved from an aerobic Malawimonas-related loukozoan. Sterols and phosphatidylinositol (PI) probably evolved in the ancestral stem actinobacterium but the ancestral hyperthermophilic archaebacterium lost them when isoprenoid ethers replaced acyl ester lipids.

Back to article page